Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents
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چکیده
منابع مشابه
Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents.
BACKGROUND The authors evaluated the comparative effectiveness of calabadion 2 to reverse non-depolarizing neuromuscular-blocking agents (NMBAs) by binding and inactivation. METHODS The dose-response relationship of drugs to reverse vecuronium-, rocuronium-, and cisatracurium-induced neuromuscular block (NMB) was evaluated in vitro (competition binding assays and urine analysis), ex vivo (n =...
متن کاملPharmacodynamics of non-depolarizing neuromuscular blocking agents.
When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
متن کاملCalabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents.
INTRODUCTION To evaluate whether calabadion 1, an acyclic member of the Cucurbit[n]uril family of molecular containers, reverses benzylisoquinoline and steroidal neuromuscular-blocking agent effects. METHODS A total of 60 rats were anesthetized, tracheotomized, and instrumented with IV and arterial catheters. Rocuronium (3.5 mg/kg) or cisatracurium (0.6 mg/kg) was administered and neuromuscul...
متن کاملInteractions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
In anaesthetized cats, we have confirmed that previously injected suxamethonium potentiates non-depolarizing neuromuscular blocking drugs whereas, when injected during the block, suxamethonium antagonizes the paralysis. We have attempted to explain these interactions by studying the effects of suxamethonium on extracellularly recorded nerve ending waveforms that correspond to the ionic currents...
متن کاملErratum: Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents
[This corrects the article on p. 500 in vol. 70, PMID: 29046769.].
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2015
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000000868